Abstract Negative pressure wound therapy with hindigyanvishv.com instillation and dwell time (NPWTi-d) is increasingly used for a diverse range of wounds.Meanwhile, the topical wound irrigation solution consisting of polyhexamethylene biguanide and betaine (PHMB-B) has shown efficacy in managing wound infections.However, the effectiveness of this solution as a topical instillation solution for NPWTi-d in patients with diabetic foot infections (DFIs) has not been thoroughly studied.The objective of this retrospective study was to evaluate the impact of using PHMB-B as the instillation solution during NPWTi-d on reducing bioburden and improving clinical outcomes in patients with DFIs.Between January 2017 and December 2022, a series of patients with DFIs received treatment with NPWTi-d, using either PHMB-B or normal saline as the instillation solution.
Data collected retrospectively included demographic information, baseline wound characteristics, and treatment outcomes.The study included 61 patients in the PHMB-B group and 73 patients in the normal saline group, all diagnosed with DFIs.In comparison to patients treated with normal saline, patients with PHMB-B exhibited no significant differences in terms of wound bed preparation time (P click here = 0.5034), length of hospital stay (P = 0.6783), NPWTi-d application times (P = 0.
1458), duration of systematic antimicrobial administration (P = 0.3567), or overall cost of hospitalization (P = 0.6713).The findings of the study suggest that the use of either PHMB-B or normal saline as an instillation solution in NPWTi-d for DFIs shows promise and effectiveness, yet no clinical distinction was observed between the two solutions.